HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → 2-(trimethylsilyl)ethyl (1RS,2SR)-2-aminocyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | 2-(trimethylsilyl)ethyl(1RS,2SR)-2-[(t-butoxycarbonyl)amino]cyclohexanecarboxylate | HCID 72303444 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(trimethylsilyl)ethyl (1RS,2SR)-2-aminocyclohexanecarboxylate | HCID 72303314 | 115.1% |
Reaction Steps
To a solution of 2.82 g of 2-(trimethylsilyl)ethyl(1RS,2SR)-2-[(t-butoxycarbonyl)amino]cyclohexanecarboxylate in 10 ml of ethyl acetate, were added 20 ml of 4 M hydrogen chloride/ethyl acetate under ice-cooling, followed by stirring at room temperature for 6 hours. The reaction solution was evaporated to obtain 2.30 g of 2-(trimethylsilyl)ethyl(1RS,2SR)-2-aminocyclohexanecarboxylate as a colorless amorphous substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486970B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-879616591bc8486c88fa0de27a99519c |
| Source note | uspto-grants-2013_07 |