HCID 23525919, compound → HCID 22641927, compound

HRID 450774Notes

Reaction equation

HRID 450774 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[C:11]([CH2:18][C:19]([OH:21])=[O:20])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:12](=[CH:16][CH:17]=1)[C:13](=[O:15])[O:21][C:19](=[O:20])[CH2:18]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 23525919HCID 23525919, compound

Product 1

HCID 22641927HCID 22641927, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6367Acetyl chlorideSolvent

Procedure

A mixture of 8 g of 4-(benzyloxy)-2-(carboxymethyl)benzoic acid and 30 ml of acetyl chloride was heated under reflux for 3 hours. The reaction solution was concentrated under reduced pressure, added with ether, and collected by filtration to obtain 7.50 g of 6-(benzyloxy)-1H-isochromene-1,3(4H)-dione as a dark brown solid.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. additionadded with ether
  5. filtrationcollected by filtration

Sources & evidence

ORD record
ord-b3ec8adfd12d4eaa817e1d212e787803
Source dataset
uspto-grants-2013_07
Patent number
US08486970B2

Reaction notes

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