反应详情

A solution of sodium methanolate (0.07 g, 1.3 mmol) in methanol is added to a solution of ω-(2-cyano-4-chlorophenoxy)-2-benzyloxy-acetophenone (0.5 g, 1.32 mmol) in methanol (30 ml) at 0° C. After 2 h at r.t. the reaction mixture is concentrated under reduced pressure. The residue is diluted with ethyl acetate and washed with water. Drying over sodium sulfate, filtering, evaporating the solvent and purification of the residue by silicagel column chromatography yields the title compound, having a m.p. of 158-160° C.

1. concentrationAfter 2 h at r.t. the reaction mixture is concentrated under reduced pressure
2. additionThe residue is diluted with ethyl acetate
3. washwashed with water
4. dry with materialDrying over sodium sulfate
5. filtrationfiltering
6. customevaporating
7. customthe solvent and purification of the residue by silicagel column chromatography