3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran → 3-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

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Reaction Steps

3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran (Example 1, 0.5 g, 1.3 mmol) in ethyl acetate (15 ml) is stirred at room temperature under an atmosphere of hydrogen in the presence of palladium on charcoal (0.025 g). After 3 h the mixture is filtered over Celite® and evaporated to dryness. Purification of the residue by chromatography yields the title compound, having a m.p. of 208-210° C.

Provenance & Evidence