Bromine → HCID 87765691, compound

HRID 450847Notes

Reaction equation

HRID 450847 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:22][CH2:23][CH3:24])=[C:8]([CH:21]=1)[C:9]([O:11][CH2:12][C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14])=[O:10]>C(OCC)C>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:22][CH2:23][CH3:24])=[C:8]([CH:21]=1)[C:9]([O:11][CH:12]([Br:1])[C:13]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:14])=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 69282321HCID 69282321, compound

Product 1

HCID 87765691HCID 87765691, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (0.6 g, 3.7 mmol) is added dropwise to a solution of 5-chloro-2-(2-ethoxybenzoyloxy)-acetophenone (1.19 g, 3.7 mmol) in dry diethyl ether (30 ml) at room temperature. The mixture is stirred for an additional hour. The reaction mixture is washed with brine and dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound in pure form.

Workup

  1. washThe reaction mixture is washed with brine
  2. dry with materialdried over sodium sulfate
  3. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-9bedb6bde2ba4f55b0dbde2483950dd9
Source dataset
uspto-grants-2013_07
Patent number
US08486996B2

Reaction notes

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