Potassium Carbonate → 3-Amino-2-(2'-ethoxy-5-fluorobenzoyl)-thieno[2,3-b]pyridine

Participants

Reaction Steps

A suspension of potassium carbonate (0.189 g, 1.37 mmol), 2-ethoxy-5-fluorophenacyl bromide and 2-mercaptonicotine nitrile in dry DMF (8 ml) is stirred at room temperature for 16 h. The resulting mixture is diluted with ethyl acetate and washed with water. Drying over sodium sulfate, filtering, evaporating the solvent and purification of the residue by silicagel column chromatography yields the title compound, having a m.p. of 130° C.

Provenance & Evidence