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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 450894Generated: October 30, 2026

Sodium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxo-2-butenoic acid

https://huagongshe.com/reaction/450894

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantEthyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoateHCID 73856874—
SolventEthanolHCID 702—
Product4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxo-2-butenoic acidHCID 73856873—

Reaction Steps

To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoate (Step E) in abs ethanol at low temp, add aqueous sodium hydroxide, after an hour, concentrate and purify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08487000B2
Source datasetuspto-grants-2013_07
ORD IDord-e5e7db847f6b4876bc70f087e487d9f3
Source noteuspto-grants-2013_07