2-Thiophenecarboxaldehyde → HCID 68798830, compound

HRID 450908Notes

Reaction equation

HRID 450908 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([O:21][CH3:22])[C:17]=1[CH:18]([CH3:20])[CH3:19])[CH2:6]P(=O)(OCC)OCC.[S:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[CH:28]=O>>[CH3:22][O:21][C:16]1[CH:15]=[C:5]([CH:6]=[CH:28][C:24]2[S:23][CH:27]=[CH:26][CH:25]=2)[CH:4]=[C:3]([O:2][CH3:1])[C:17]=1[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 73642-ThiophenecarboxaldehydeHCID 46928247Diethyl (4-isopropyl-3,5-dimethoxybenzyl)phosphonate

Product 1

HCID 68798830HCID 68798830, compoundYield 78%

Procedure

This material was prepared from diethyl (3,5-dimethoxy-4-i-propylbenzyl)phosphonate obtained in example 15(a) and thiophene carboxaldehyde in 78% yield as the same way as described in the example 15(b), 1HNMR (CDCl3, ppm): δ 1.32 (d, J=7.1 Hz, 6H), 3.70 (qint., J=7.1 Hz, 1H), 3.89 (s, 6H), 6.69 (s, 2H), 6.90 (d, J=16 Hz, 1H), 7.0-7.3 (m, 4H).

Sources & evidence

ORD record
ord-7d7450cbb17e494cbb3b9db56f42a897
Source dataset
uspto-grants-2013_07
Patent number
US08487009B2

Reaction notes

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