HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 1-Bromo-4-(1-isocyanatoethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Bromo-4-(1-isocyanatoethyl)benzene | HCID 610983 | — |
Reaction Steps
To a solution of (S)-1-(4-bromophenyl)ethanamine (40 g, 0.2 mol) in methylene chloride (600 mL) and satd aq NaHCO3 (600 mL) was added triphosgene (27 g, 0.025 mol) at 0° C. The mixture was stirred for 15 min. The organic phase was separated, dried and concentrated to give 1-bromo-4-(1-isocyanato-ethyl)-benzene (35 g, crude).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08487094B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-24c45b178e0f4c8fb70c6cecca0b14c8 |
| Source note | uspto-grants-2013_07 |