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HRID451045

反应详情

EQUATION

反应方程式

HRID 451045 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

结构：Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1
HCID58075424

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2nc(Cl)nc3c2CCC3c2ccc(F)cc2)CC1
HCID58075703

未命名化合物

收率 76.5%

PROCEDURE

实验过程

2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine (Preparation H) (100 mg, 0.353 mmol) and tert-Butyl 1-piperazinecarboxylate (65.8 mg, 0.353 mmol) were combined and purified as per Preparation Hb to give tert-butyl 4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (116.9 mg, 76% yield). LC-MS (M+H)+=433.3.

WORKUP

后处理

  1. custompurified as per Preparation Hb