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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 451114Generated: October 29, 2026

4-(Trifluoromethyl)phenylboronic acid → 3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one

https://huagongshe.com/reaction/451114

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Reactant3-iodo-4,4-dimethoxytetrahydro-2H-pyranHCID 58075384—
Product3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-oneHCID 58075307—

Reaction Steps

4-(trifluoromethyl)phenylboronic acid was reacted as described in Intermediate X(2) with 3-iodo-4,4-dimethoxytetrahydro-2H-pyran (Intermediate X(1)) to give 3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one (Intermediate Z(2)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08486952B2
Source datasetuspto-grants-2013_07
ORD IDord-26ead61450d24246b54e63dfd97eefde
Source noteuspto-grants-2013_07