HCID 58075703, compound → HCID 58075688, compound

HRID 451161Notes

Reaction equation

HRID 451161 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1.[Cl:31][C:32]1[N:33]=[CH:34][N:35]([C:37]2[CH:43]=[CH:42][C:40]([NH2:41])=[CH:39][C:38]=2[O:44][CH3:45])[CH:36]=1>>[Cl:31][C:32]1[N:33]=[CH:34][N:35]([C:37]2[CH:43]=[CH:42][C:40]([NH:41][C:2]3[N:3]=[C:4]([N:18]4[CH2:19][CH2:20][N:21]([C:24]([O:26][C:27]([CH3:29])([CH3:30])[CH3:28])=[O:25])[CH2:22][CH2:23]4)[C:5]4[CH2:10][CH2:9][CH:8]([C:11]5[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=5)[C:6]=4[N:7]=3)=[CH:39][C:38]=2[O:44][CH3:45])[CH:36]=1

Participants

3

Reactant 2

HCID 58075703HCID 58075703, compoundHCID 580757574-(4-chloro-1H-imidazol-1-yl)-3-methoxyaniline

Product 1

HCID 58075688HCID 58075688, compoundYield 62.1%

Procedure

tert-butyl 4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (Preparation Hl) (117 mg, 0.270 mmol) and 4-(4-chloro-1H-imidazol-1-yl)-3-methoxyaniline (Preparation A) (60.4 mg, 0.270 mmol) were combined as per Example 26 to give tert-butyl 4-(2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (104 mg, 0.168 mmol, 62.1% yield) crude without purification. LC-MS (M+H)+=620.4.

Sources & evidence

ORD record
ord-b0640e2e905149269f6ff101b9631dda
Source dataset
uspto-grants-2013_07
Patent number
US08486952B2

Reaction notes

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