HCID 58075285, compound → HCID 58075767, compound

HRID 451164Notes

Reaction equation

HRID 451164 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:18]2[CH2:21][CH:20]([N:22]([CH3:30])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:19]2)[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1.[Cl:31][C:32]1[N:33]=[CH:34][N:35]([C:37]2[CH:43]=[CH:42][C:40]([NH2:41])=[CH:39][C:38]=2[O:44][CH3:45])[CH:36]=1>>[Cl:31][C:32]1[N:33]=[CH:34][N:35]([C:37]2[CH:43]=[CH:42][C:40]([NH:41][C:2]3[N:3]=[C:4]([N:18]4[CH2:19][CH:20]([N:22]([CH3:30])[C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:28])[CH3:27])[CH2:21]4)[C:5]4[CH2:10][CH2:9][CH:8]([C:11]5[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=5)[C:6]=4[N:7]=3)=[CH:39][C:38]=2[O:44][CH3:45])[CH:36]=1

Participants

3

Reactant 2

HCID 58075285HCID 58075285, compoundHCID 580757574-(4-chloro-1H-imidazol-1-yl)-3-methoxyaniline

Product 1

HCID 58075767HCID 58075767, compoundYield 49.4%

Procedure

tert-butyl 1-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)azetidin-3-yl(methyl)carbamate (Preparation Hn) (147 mg, 0.340 mmol) and 4-(4-chloro-1H-imidazol-1-yl)-3-methoxyaniline (Preparation A) (76 mg, 0.340 mmol) were combined as per Example 26 to give the crude tert-butyl 1-(2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)azetidin-3-yl(methyl)carbamate (104 mg, 0.168 mmol, 49.4% yield) which was used without further purification. LC-MS (M+H)+=620.4.

Sources & evidence

ORD record
ord-8ee304e3923d444ca691a137db72dd55
Source dataset
uspto-grants-2013_07
Patent number
US08486952B2

Reaction notes

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