HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Heptyne → N-(2-Hept-1ynyl-phenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Heptyne | HCID 12350 | — |
| Reactant | N-Acetyl-O-p-toluenesulfonyl-2-aminophenol | HCID 572553 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-(2-Hept-1ynyl-phenyl)-acetamide | HCID 25221491 | — |
Reaction Steps
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 8:2; yield (92 mg, 80%); 1H NMR δ (CDCl3): 8.47 (d, J=8.51 Hz, 1H), 7.93 (br s, 1H), 7.36 (dm, 1H), 7.31-7.23 (m, 1H), 7.02 (t, J=7.22 Hz, 1H), 2.53 (t, J=7.08 Hz, 2H), 2.21 (s, 3H), 1.63 (p, J=7.11 Hz, 2H), 1.48-1.3 (m, 4H), 0.92 (t, J=7.2 Hz, 3H); LCMS m/z: 229.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08487109B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-7fd335d18fb142e68d695073438d98ff |
| Source note | uspto-grants-2013_07 |