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Phenylacetylene → Acetamide, N-[2-(phenylethynyl)phenyl]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylacetylene | HCID 10821 | — |
| 反応物 | N-Acetyl-O-p-toluenesulfonyl-2-aminophenol | HCID 572553 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | Acetamide, N-[2-(phenylethynyl)phenyl]- | HCID 2749414 | — |
反応手順
This product was prepared from toluene-4-sulfonic acid 2-acetylamino-phenyl ester and ethynyl-benzene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 9:1; yield (60 mg, 50%); 1H NMR δ (CDCl3): 8.39 (d, J=8.55 Hz, 1H), 7.9 (br s, 1H), 7.59-7.67 (m, 2H), 7.58-7.52 (m, 2H), 7.41-7.35 (m, 3H), 7.02 (t, J=7.22 Hz, 1H), 2.21 (s, 3H); LCMS m/z: 235.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487109B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-e323057205b2480987423b3ad85724f1 |
| 出典メモ | uspto-grants-2013_07 |