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HRID 451260作成日：2026年10月25日

1-Ethynylcyclohexene → 1-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanone

https://huagongshe.com/reaction/451260

反応式

関与物質

役割名称HCID仕込み量
反応物1-EthynylcyclohexeneHCID 79128—
反応物Toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl esterHCID 29800848—
溶媒DichloromethaneHCID 6344—
生成物1-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanoneHCID 25221607—

反応手順

This product was prepared from toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: DCM; yield (114 mg, 90%); 1H NMR δ (CDCl3): 7.53-7.41 (m, 3H), 6.29 (m, 1H), 3.92 (s, 3H), 2.51 (s, 3H), 2.31-2.12 (dm, 4H), 1.73-1.57 (m, 4H); LCMS m/z: 254.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08487109B2
出典データセットuspto-grants-2013_07
ORD IDord-dc315de689f544b883d3cae1f9f48485
出典メモuspto-grants-2013_07