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1-Heptyne → 4-Hept-1-ynyl-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Heptyne | HCID 12350 | — |
| 反応物 | 4-(((4-Methylphenyl)sulfonyl)oxy)benzaldehyde | HCID 5125086 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | 4-Hept-1-ynyl-benzaldehyde | HCID 25221612 | — |
反応手順
This product was prepared from toluene-4-sulfonic acid 4-formyl-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/EtOAc 9:1; yield (60 mg, 70%); 1H NMR δ (CDCl3): 10.02 (s, 1H), 7.8 (d, J=8.65 Hz, 2H), 7.53 (d, J=8.62 Hz, 2H), 2.45 (t, J=7.22 Hz, 2H), 1.62 (p, J=7.11 Hz, 2H), 1.48-1.3 (m, 4H), 0.93 (t, J=7.20 Hz, 3H); LCMS m/z: 200
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08487109B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-742cc869eb344db2b9fc101f1923d35a |
| 出典メモ | uspto-grants-2013_07 |