1-Heptyne → HCID 25221728, compound

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Reaction Steps

This product was prepared from toluene-4-sulfonic acid 3-chloro-5-fluoro-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane; yield (110 mg, 98%); 1H NMR δ (CDCl3): 7.16 (s, 1H), 7.02-6.94 (m, 2H), 2.43 (t, J=7.13 Hz, 2H), 1.62 (p, J=7.12 Hz, 2H), 1.45-1.29 (m, 4H), 0.92 (t, J=7.22 Hz, 3H); LCMS m/z: 224.

Provenance & Evidence