Acetone → HCID 68736761, compound

Participants

Reaction Steps

Sodium 2-ethylhexanoate (0.5 M in ethyl acetate, 2.5 mL, 1.25 mmol) was added to a solution of allyl (4R,6S)-3-(benzyloxy)-2-oxo-1,3-diazabicyclo[2.2.1]heptane-6-carboxylate (459 mg, 1.52 mmol), 1,1′-bis(diphenyl-phosphino)ferrocene-palladium(II)dichloride dichloromethane complex (116 mg, 0.14 mmol) in tetrahydrofuran (7.6 mL). The reaction mixture was stirred at room temperature for 2 hours (precipitate formed). Acetone (37 mL) was added. The resulting mixture was stirred at room temperature for 2 hours and the mixture was centrifuged. The solid was collected and washed with acetone and ether and dried under vacuum to afford the title compound as a tan solid. LC-MS (positive ionization) m/e 363 (M+H)

Provenance & Evidence