HCID 86659588, compound → HCID 86659590, compound

HRID 451305Notes

Reaction equation

HRID 451305 reaction equation
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][C@@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)=[O:19])C1C=CC=CC=1>[Pd].CO>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][C@@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)=[O:19]

Participants

4

Reactant 1

HCID 86659588HCID 86659588, compound

Product 1

HCID 86659590HCID 86659590, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon (9.18 mg; 10% Pd/C) was added to a solution of tert-butyl (3R)-3-({[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)pyrrolidine-1-carboxylate (38 mg, 0.085 mmol) in methanol (2 mL) and the resulting mixture was stirred under hydrogen (balloon) for 3 hours. TLC analysis showed the reaction was complete. The reaction mixture was filtered through a microfilter and the filtrate was concentrated under vacuum to afford the impure title compound as an oil.

Workup

  1. filtrationThe reaction mixture was filtered through a microfilter
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-95bbd35f5dd14bd5b3d6612f9fc8932f
Source dataset
uspto-grants-2013_07
Patent number
US08487093B2

Reaction notes

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