HCID 58530129, compound → HCID 58530021, compound

Participants

Reaction Steps

Palladium on carbon (13.2 mg; 10% Pd/C) was added to a solution of (2S,5R)-6-(benzyloxy)-7-oxo-N-pyridin-4-yl-1,6-diazabicyclo[3.2.1]octane-2-carboxamide (52.7 mg, 0.15 mmol; combined product of two runs) in methanol (1.5 mL) and the resulting mixture was stirred under hydrogen (balloon) for 5 hours. TLC and HPLC analysis showed a small amount of starting material remaining. Additional catalyst (5.6 mg) was added and the resulting mixture was stirred under hydrogen (balloon) for an additional 1 hour. The reaction mixture was filtered through a microfilter and the filtrate was concentrated under vacuum to afford the title compound as a colorless oil.

Provenance & Evidence