Tributylstannane → HCID 70993762, compound

Participants

Reaction Steps

AIBN (0.1 eq.) is added to a solution of tert-butyl 4-[({(2S,5R)-7-oxo-6-[(phenoxycarbonothioyl)oxy]-1,6-diazabicyclo[3.2.1]oct-2-yl}carbonyl)amino]piperidine-1-carboxylate in dry benzene and the resulting mixture is heated to reflux. A solution of tributyltin hydride (1.25 eq.) in benzene is added over a period of one hour and the resulting mixture is refluxed for an additional 3 hours. The reaction mixture is concentrated under vacuum and the residue is purified by silica gel chromatography to afford the title compound.

Provenance & Evidence