Sulfur trioxide-pyridine → HCID 86659600, compound

HRID 451326Notes

Reaction equation

HRID 451326 reaction equation
[OH:1][N:2]1[C:8](=[O:9])[N:7]2[CH2:10][C@H:3]1[CH2:4][CH2:5][C@H:6]2[C:11]([O:13][CH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]1)=[O:12].[S:28](=[O:31])(=[O:30])=[O:29].N1C=CC=CC=1>N1C=CC=CC=1>[O:9]=[C:8]1[N:7]2[CH2:10][C@@H:3]([CH2:4][CH2:5][C@H:6]2[C:11]([O:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]2)=[O:12])[N:2]1[O:1][S:28]([OH:31])(=[O:30])=[O:29]

Participants

4

Reactant 2

HCID 168533Sulfur trioxide-pyridineHCID 86659599HCID 86659599, compound

Product 1

HCID 86659600HCID 86659600, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of the product of Step 2 (50 mg, 0.13 mmol) in dry pyridine (1 mL) was added pyridine sulfur trioxide (104 mg, 0.652 mmol) at room temperature under nitrogen. The reaction mixture was stirred overnight then filtered (collected solid was washed well with dichloromethane). The filtrate was concentrated under vacuum to afford the title compound which was used without purification in the next step.

Workup

  1. filtrationthen filtered (
  2. customcollected solid
  3. washwas washed well with dichloromethane)
  4. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-3c24ea4f228f498f892e2f09cc8bdc42
Source dataset
uspto-grants-2013_07
Patent number
US08487093B2

Reaction notes

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