Trifluoroacetic acid → HCID 44184100, compound

Participants

Reaction Steps

TFA was added to the product of Step 3 at 0° C. under nitrogen. The reaction mixture was stirred for 1 hour then concentrated under vacuum. The residue was triturated with ether to remove excess trifluoroacetic acid and organic-soluble impurities. The resulting solid was dried, dissolved in water, and purified by preparative HPLC on a Phenomenex Synergy Polar-RP 80A column eluted with methanol/water and lyophilized to afford the title compound. LC-MS (negative ionization mode) m/e 362 (M−H).

Provenance & Evidence