Acetic Acid → HCID 86644231, compound

Participants

Reaction Steps

To a solution of 30 g of ethyl 4-chloroacetoacetate in 90 ml of toluene and 30 ml of ethanol are added 2 ml of acetic acid. At 10° C.-30° C., with cooling, 8.9 g of ethylamine are added dropwise. Subsequently, the mixture is stirred at room temperature for 6 h and the solvent is removed under reduced pressure at temperatures of down to 35° C. 37.7 g of ethyl 4-chloro-3-(ethylamino)but-2-enecarboxylate are obtained in a purity of 88% (this corresponds to 98% yield).

Provenance & Evidence