Acetic Acid → HCID 86644232, compound

Participants

Reaction Steps

To a solution of 100 g of ethyl 4-chloroacetoacetate in 300 ml of toluene and 100 ml of ethanol are added 7 ml of acetic acid. At 10° C.-30° C., with cooling, 37.3 g of n-propylamine are added dropwise. Subsequently, the mixture is stirred at room temperature for 9 h and the solvent is removed under reduced pressure at temperatures of down to 35° C. 140.6 g of ethyl 4-chloro-3-(n-propylamino)but-2-enecarboxylate are obtained in a purity of 76% (this corresponds to 88% yield).

Provenance & Evidence