Acetic Acid → HCID 86644236, compound

Participants

Reaction Steps

To a solution of 100 g of ethyl 4-chloroacetoacetate in 300 ml of toluene and 100 ml of ethanol are added 6.7 ml of acetic acid. At 10° C.-30° C., with cooling, 46.5 g of 2-methoxyethylamine are added dropwise. Subsequently, the mixture is stirred at room temperature for 8 h and the solvent is removed under reduced pressure at temperatures of down to 35° C. 140.8 g of ethyl 4-chloro-3-(2-methoxyethylamino)but-2-enecarboxylate are obtained in a purity of 88% (this corresponds to 95% yield).

Provenance & Evidence