Acetic Acid → HCID 86644237, compound

Participants

Reaction Steps

To a solution of 2.1 g of ethyl 4-chloroacetoacetate in 12 ml of toluene is added 0.15 ml of acetic acid. At 10° C.-30° C., with cooling, 2 g of 2-chloro-5-(aminomethyl)pyridine dissolved in 4 ml of ethanol are added dropwise. Subsequently, the mixture is stirred at room temperature for 8 h and the solvent is removed under reduced pressure at temperatures of down to 35° C. 4.2 g of ethyl 4-chloro-3-([[6-chloropyridin-3-yl]methyl]amino)but-2-enecarboxylate are obtained in a purity of 86% (this corresponds to 98% yield).

Provenance & Evidence