Acetic Acid → HCID 86658840, compound

Participants

Reaction Conditions

Reaction Steps

To 60 ml of acetic acid 40 g of the tizanidine base (99.15% HPLC) are gradually added under stirring and heating until a yellow solution is obtained at 70 to 80° C., to which 200 ml of acetone are added. Shortly thereafter crystallization begins. After cooling to 0 to 5° C. and aspiration 47.25 g of tizanidine acetate (i.e. 95.5% th.) are obtained.

Provenance & Evidence