Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tizanidine | HCID 5487 | — |
| Reactant | Ethoxyacetic acid | HCID 12301 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86658845 | HCID 86658845 | 90.1% |
Reaction Steps
To a solution of 2.0 g of ethoxyacetic acid in 4 ml of isopropyl alcohol, 3.0 g of the tizanidine base (99.15% HPLC) are added. After brief heating to boil a solution results, from which a crystalline precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 3.8 g of tizanidine ethoxyacetate are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08487113B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-aada971cc9ce4c25a917ee25219ca576 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
