Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tizanidine | HCID 5487 | — |
| Reactant | Dichloroacetic Acid | HCID 6597 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86658847 | HCID 86658847 | 92% |
Reaction Steps
To a solution of 3.0 g of dichloroacetic acid in 5 ml of isopropyl alcohol, 3.0 g of tizanidine base (99.15% HPLC) are added. After short heating to boil a solution results, from which, after addition of ethyl acetate, a crystalline precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 4.15 g tizanidine dichloroacetate are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08487113B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-a76f4316c1324e62a052afd0e8706580 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
