反应详情

温度

80 °C

To a solution of methyl 5-[4-chloro-2-(trifluoromethyl)phenyl]-4-methyl-1H-pyrrole-3-carboxylate (0.39 g, 1.3 mmol) in methanol (5.0 ml) was added 5N NaOH (5.0 ml) and the mixture was stirred at 80° C. for 3.0 h. The reaction mixture was cooled to room temperature and added formic acid (3.0 ml). The mixture was concentrated on a rotary evaporator. To the residue was added water and triturated. The solid was filtered and dried to give the title compound (0.37 g, 93%) as a brown solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationThe mixture was concentrated on a rotary evaporator
3. additionTo the residue was added water
4. customtriturated
5. filtrationThe solid was filtered
6. customdried