反应详情

温度

80 °C

To a solution of methyl 5-(2-chloro-4-fluorophenyl)-4-methyl-1H-pyrrole-3-carboxylate (0.64 g, 2.4 mmol) in methanol (10 ml) was added 5N NaOH (10 ml) and the mixture was stirred at 80° C. for 4.0 h. The reaction mixture was concentrated on a rotary evaporator. To the residue was added water and washed with Et2O. The resulting solution was neutralized with conc HCl and extracted with ethyl acetate. The organic layer was washed with water and brine, then dried over sodium sulfate and concentrated on a rotary evaporator to give the title compound (610 mg, quant) as a brown solid.

1. concentrationThe reaction mixture was concentrated on a rotary evaporator
2. additionTo the residue was added water
3. washwashed with Et2O
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with water and brine
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated on a rotary evaporator