1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one → HCID 53354733, compound

HRID 451387Notes

Reaction equation

HRID 451387 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[S:4][N:3]=1.[F:14][C:15]1[CH:16]=[C:17]([CH:25]=[C:26]([F:29])[C:27]=1[F:28])[CH2:18][N:19]1[CH:23]=[N:22][C:21]([NH2:24])=[N:20]1>>[CH3:1][C:2]1[N:6]=[C:5]([N:7]2[CH2:12][CH2:11][CH:10]([NH:24][C:21]3[N:22]=[CH:23][N:19]([CH2:18][C:17]4[CH:25]=[C:26]([F:29])[C:27]([F:28])=[C:15]([F:14])[CH:16]=4)[N:20]=3)[CH2:9][CH2:8]2)[S:4][N:3]=1

Participants

3

Reactant 2

HCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-oneHCID 67343001HCID 67343001, compound

Product 1

HCID 53354733HCID 53354733, compound

Procedure

Prepared in analogy to example 1 step h) starting from 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one (example 1c) and 1-(3,4,5-trifluoro-benzyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a yellow solid.

Workup

  1. customPrepared in analogy to example 1 step h)

Sources & evidence

ORD record
ord-e0608736b8af446cb92bde8dc1fa0a93
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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