tert-Butyl 4-oxopiperidine-1-carboxylate → 4-[1-(2,4-Dichloro-phenyl)-5-methyl-1H-[1,2,4]triazol-3-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 451395Notes

Reaction equation

HRID 451395 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=1[N:23]1[C:27]([CH3:28])=[N:26][C:25]([NH2:29])=[N:24]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:29][C:25]2[N:26]=[C:27]([CH3:28])[N:23]([C:17]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:16]=3[Cl:15])[N:24]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 673416041-(2,4-dichlorophenyl)-5-methyl-1H-1,2,4-triazol-3-amine

Product 1

HCID 673419754-[1-(2,4-Dichloro-phenyl)-5-methyl-1H-[1,2,4]triazol-3-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to example 1 step h) starting from 4-oxo-piperidine-1-carboxylic acid tert-butyl ester and 1-(2,4-dichloro-phenyl)-5-methyl-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a light yellow solid (yield=34%).

Workup

  1. customPrepared in analogy to example 1 step h)

Sources & evidence

ORD record
ord-140dc20723dc4a6195a9a158a839ee95
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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