Ammonium Chloride → 2-Chloro-4-(4-chloro-benzyl)-6-(1-methyl-1-trimethylsilanyloxy-ethyl)-pyrimidine

Temperature

50 °C

To a solution of 2,4-dichloro-6-(1-methyl-1-trimethylsilanyloxy-ethyl)-pyrimidine (5.02 g, 18.0 mmol) in THF (60 mL) was added Pd(TPP)4 (0.83 g, 0.72 mmol). The solution was flushed with argon, and subsequently, a 0.5 M solution of 4-chloro-benzylzinc chloride in tetrahydrofuran (36 mL, 18.0 mmol) was added at 20° C. over 1-3 minutes. The reaction mixture was heated to 50° C. for 3 h under an atmosphere of argon. After cooling the mixture to 20° C., saturated aqueous ammonium chloride solution (30 mL) was added to quench the reaction. The mixture was extracted with ethyl acetate (2×30 mL) and the organic layers were washed with brine (2×30 mL), dried over sodium sulfate, and evaporated under reduced pressure. The residual oil was purified by chromatography on silica gel using heptane/0-30% ethyl acetate as eluent to afford the title compound (4.72 g, 71%) as a colorless oil.

1. customThe solution was flushed with argon
2. temperatureAfter cooling the mixture to 20° C.
3. customto quench
4. customthe reaction
5. extractionThe mixture was extracted with ethyl acetate (2×30 mL)
6. washthe organic layers were washed with brine (2×30 mL)
7. dry with materialdried over sodium sulfate
8. customevaporated under reduced pressure
9. customThe residual oil was purified by chromatography on silica gel

ORD record

ord-6cf2daf7e82d486e9ef84696b532297b

Source dataset

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08486967B2