1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one → HCID 53353626, compound

HRID 451439Notes

Reaction equation

HRID 451439 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]3[N:14]=[C:15]([NH2:17])[N:16]=[C:12]3[CH:11]=[N:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:18][C:19]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]2)[S:21][N:20]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]3[N:14]=[C:15]([NH:17][CH:27]4[CH2:26][CH2:25][N:24]([C:22]5[S:21][N:20]=[C:19]([CH3:18])[N:23]=5)[CH2:29][CH2:28]4)[N:16]=[C:12]3[CH:11]=[N:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-oneHCID 67335189HCID 67335189, compound

Product 1

HCID 53353626HCID 53353626, compound

Procedure

Prepared in analogy to example 1h, starting from 5-(4-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine and 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one. The title compound was obtained as a white solid.

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-83a6eab434d740bca5503915ba2b139b
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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