1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one → [8-(3,4-Difluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one	HCID 59258510	—
Reactant	8-(3,4-Difluorophenyl)-[1,2,4]triazolo[1,5-A]pyridin-2-amine	HCID 67337204	—
Product	[8-(3,4-Difluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine	HCID 53353628	—

Reaction Steps

Prepared in analogy to example 1h, starting from 8-(3,4-difluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine and 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one. The title compound was obtained as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08486967B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-3a14817c1a0f4633afdab62451d29f7b
Source note	uspto-grants-2013_07