1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one → HCID 53353627, compound

HRID 451441Notes

Reaction equation

HRID 451441 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH2:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8].[CH3:19][C:20]1[N:24]=[C:23]([N:25]2[CH2:30][CH2:29][C:28](=O)[CH2:27][CH2:26]2)[S:22][N:21]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][CH:28]4[CH2:27][CH2:26][N:25]([C:23]5[S:22][N:21]=[C:20]([CH3:19])[N:24]=5)[CH2:30][CH2:29]4)[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-oneHCID 67344402HCID 67344402, compound

Product 1

HCID 53353627HCID 53353627, compound

Procedure

Prepared in analogy to example 1h, starting from 8-(3-Chloro-4-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine and 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one. The title compound was obtained as a white solid.

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-6cf8c6138ebe4814ab45a3a076ef4290
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

Loading…