Ethyl isothiocyanatoformate → Carbamic acid, N-[[(3-bromo-5-cyclopropyl-2-pyridinyl)amino]thioxomethyl]-, ethyl ester

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Reaction Steps

To a solution of 3-bromo-5-cyclopropyl-pyridin-2-ylamine (1.0 g, 4.69 mmol) in dry 1,4-dioxane (20 mL) was added ethoxy carbonyl isothiocyanate (0.55 mL, 5.16 mmol) under an argon atmosphere and stirred at room temperature for 6 hours. The solvent was evaporated and the title compound was obtained as light yellow oil (1.5 g, 98%).

Provenance & Evidence