Diisopropylethylamine → 8-(2-Chloro-4-fluorophenyl)-N-(1-(2-methylpyridin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-(2-chloro-4-fluorophenyl)-N-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (69 mg, 2 mmol), 4-bromo-2-methylpyridine (34 mg, 0.2 mmol) and N,N-diisopropylethylamine (40 mg, 0.3 mmol) in 1,4-dioxane (0.8 mL) was stirred for 30 minutes at 150° C. in the microwave. Purification by chromatography of the reaction mixture (SiO2, heptane:ethyl acetate 1:1 to ethyl acetate:methanol:ammoniumhydroxide 80:18:2 afforded the title compound as yellow semisolid (21 mg, 24%).

Provenance & Evidence