HCID 61226887, compound → [8-(2-Fluoro-4-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-amine

HRID 451468Notes

Reaction equation

HRID 451468 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)[CH:3]=1.[F:15][C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:17]=1[CH:26]1[CH2:31][CH2:30][CH2:29][N:28]2[N:32]=[C:33]([NH2:35])[N:34]=[C:27]12>>[F:15][C:16]1[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:19]=[CH:18][C:17]=1[CH:26]1[CH2:31][CH2:30][CH2:29][N:28]2[N:32]=[C:33]([NH:35][CH:11]3[CH2:12][CH2:13][N:8]([C:4]4[CH:3]=[C:2]([CH3:1])[N:7]=[CH:6][N:5]=4)[CH2:9][CH2:10]3)[N:34]=[C:27]12

Participants

3

Reactant 2

HCID 61226887HCID 61226887, compoundHCID 673455988-(2-Fluoro-4-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 53354324[8-(2-Fluoro-4-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-amine

Procedure

Prepared in analogy to example 1h employing 1-(6-methylpyrimidin-4-yl)piperidin-4-one and 8-(2-fluoro-4-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (prepared in analogy to example 1d-g). The title compound was obtained as light yellow foam. MS ISP (m/e): 476.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-423723af5e264197902b0a40d808305f
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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