1-(5-Methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-one → [8-(4-Fluoro-3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-yl]-amine

HRID 451470Notes

Reaction equation

HRID 451470 reaction equation
[CH3:1][C:2]1[O:6][C:5]([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)=[N:4][N:3]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]2[CH2:26][CH2:25][CH2:24][N:23]3[N:27]=[C:28]([NH2:30])[N:29]=[C:22]23)=[CH:17][C:16]=1[C:31]([F:34])([F:33])[F:32]>>[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]2[CH2:26][CH2:25][CH2:24][N:23]3[N:27]=[C:28]([NH:30][CH:10]4[CH2:11][CH2:12][N:7]([C:5]5[O:6][C:2]([CH3:1])=[N:3][N:4]=5)[CH2:8][CH2:9]4)[N:29]=[C:22]23)=[CH:17][C:16]=1[C:31]([F:32])([F:33])[F:34]

Participants

3

Reactant 2

HCID 583978531-(5-Methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-oneHCID 673440428-(4-Fluoro-3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 58397902[8-(4-Fluoro-3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-yl]-amine

Procedure

Prepared in analogy to example 1h employing 1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-one (see example 25b) and 8-(4-fluoro-3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (prepared in analogy to example 1d-g). The title compound was obtained as brown solid.

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-81b22a52582e4d8196337ef22b5e08c4
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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