2-Bromo-8-(3-chlorophenoxy)-[1,2,4]triazolo[1,5-a]pyridine → [8-(3-Chloro-phenoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-yl]-amine

HRID 451475Notes

Reaction equation

HRID 451475 reaction equation
Br[C:2]1[N:18]=[C:5]2[C:6]([O:10][C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=3)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[CH3:19][C:20]1[O:24][C:23]([N:25]2[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]2)=[N:22][N:21]=1>>[Cl:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[O:10][C:6]1[C:5]2[N:4]([N:3]=[C:2]([NH:31][CH:28]3[CH2:29][CH2:30][N:25]([C:23]4[O:24][C:20]([CH3:19])=[N:21][N:22]=4)[CH2:26][CH2:27]3)[N:18]=2)[CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 673438602-Bromo-8-(3-chlorophenoxy)-[1,2,4]triazolo[1,5-a]pyridineHCID 673446221-(5-Methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamine

Product 1

HCID 58397935[8-(3-Chloro-phenoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-yl]-amine

Procedure

Prepared in analogy to example 66f employing 2-bromo-8-(3-chlorophenoxy)-[1,2,4]triazolo[1,5-a]pyridine (see example 152a) and 1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamine (see example 40b). The title compound was obtained as yellow oil.

Workup

  1. customPrepared in analogy to example 66f

Sources & evidence

ORD record
ord-d71d52804a64498382698f5b93069d7d
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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