HCID 61226887, compound → [8-(3-Dimethylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-amine

HRID 451476Notes

Reaction equation

HRID 451476 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)[CH:3]=1.[CH3:15][N:16]([CH3:33])[C:17]1[CH:18]=[C:19]([C:23]2[C:24]3[N:25]([N:29]=[C:30]([NH2:32])[N:31]=3)[CH:26]=[CH:27][CH:28]=2)[CH:20]=[CH:21][CH:22]=1>>[CH3:15][N:16]([CH3:33])[C:17]1[CH:18]=[C:19]([C:23]2[C:24]3[N:25]([N:29]=[C:30]([NH:32][CH:11]4[CH2:12][CH2:13][N:8]([C:4]5[CH:3]=[C:2]([CH3:1])[N:7]=[CH:6][N:5]=5)[CH2:9][CH2:10]4)[N:31]=3)[CH:26]=[CH:27][CH:28]=2)[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 61226887HCID 61226887, compoundHCID 673425328-(3-Dimethylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 58397942[8-(3-Dimethylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-amine

Procedure

Prepared in analogy to example 1h employing 1-(6-methylpyrimidin-4-yl)piperidin-4-one (see example 93b) and 8-(3-dimethylamino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (prepared in analogy to example 66a-c). The title compound was obtained as white foam.

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-b562e10e7b794d0d83e3ef844edab601
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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