Dichloromethane → HCID 67343540, compound

HRID 451494Notes

Reaction equation

HRID 451494 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][O:10][C:9]3=[N:13][C:14]([NH2:16])=[N:15][N:8]23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1[N:23]=[CH:22][N:21]=[C:20]([N:24]2[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]2)[CH:19]=1.C(Cl)Cl>C(Cl)Cl.CO>[CH3:17][C:18]1[N:23]=[CH:22][N:21]=[C:20]([N:24]2[CH2:29][CH2:28][CH:27]([NH:16][C:14]3[N:13]=[C:9]4[O:10][CH2:11][CH2:12][CH:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[N:8]4[N:15]=3)[CH2:26][CH2:25]2)[CH:19]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 61226887HCID 61226887, compoundHCID 673361667-Phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-ylamine

Product 1

HCID 67343540HCID 67343540, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared in analogy to example 1h, starting from 7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazin-2-amine and 1-(6-methylpyrimidin-4-yl)piperidin-4-one (see example 93b). The title compound was obtained as a light yellow solid (yield: 17%) after column chromatography on silica gel using a gradient from methylene chloride to methylene chloride/methanol 19:1 (v/v) as eluent. MS ISP (m/e): 392.3 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1h

Sources & evidence

ORD record
ord-fd242b4a2f314ca28a14093c6308d875
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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