Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)piperidin-4-amine dihydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 1-(2-chloropyridin-4-yl)piperidin-4-ylcarbamate (1.00 g, 3.21 mmol) in dichloromethane (16 mL) was added HCl (2 M in diethylether, 8.02 mL, 16.0 mmol) and the reaction mixture was stirred at room temperature over night for 18 hours. The mixture was then filtered off and the white precipitate washed with dichloromethane and diethylether and dried to afford the title compound (913 mg, 99%) as a white solid. MS ISP (m/e): 212.1/214.1 [(M+H)+].

Provenance & Evidence