Sodium Methoxide → HCID 58398043, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-(2-chloro-4-fluorophenyl)-N-(1-(2-chloropyrimidin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (example 190b) (71 mg, 0.155 mmol) in MeOH (1.5 mL) was added sodium methoxide solution (30% in MeOH, 35 L, 0.186 mmol) and the reaction mixture was stirred in a sealed tube under Argon at 60° C. for 18 hours and then heated in the microwave to 150° C. for 30 minutes. The mixture was then evaporated.

Provenance & Evidence