2-Chloro-5-(trifluoromethyl)phenylboronic acid → HCID 58398053, compound

HRID 451535Notes

Reaction equation

HRID 451535 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[S:22][N:21]=[C:20]([CH3:23])[N:19]=4)[CH2:14][CH2:13]3)[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=1B(O)O>>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]([F:32])([F:33])[F:34])=[CH:29][C:30]=1[C:2]1[C:3]2[N:4]([N:8]=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[S:22][N:21]=[C:20]([CH3:23])[N:19]=4)[CH2:14][CH2:13]3)[N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27826702-Chloro-5-(trifluoromethyl)phenylboronic acidHCID 67345576HCID 67345576, compound

Product 1

HCID 58398053HCID 58398053, compound

Procedure

Prepared in analogy to example 66c employing (8-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine and 2-chloro-5-(trifluoromethyl)-phenyl boronic acid. The title compound was obtained as light yellow foam.

Workup

  1. customPrepared in analogy to example 66c

Sources & evidence

ORD record
ord-0f8b8e2ab0394c45a3c1c67e8233db37
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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