反应详情

To a solution of 4-methyl-1-(6-methylpyrimidin-4-yl)piperidin-4-amine (1.09 g, 5.28 mmol) in dichloromethane (17.2 mL) was added 1,1′-thiocarbonyldipyridin-2(1H)-one (1.84 g, 7.92 mmol) and the reaction mixture was stirred at room temperature for 16 hours. After cooling to room temperature the mixture was evaporated. Purification by chromatography (silica gel, 3×70 g, 50 to 100% ethyl acetate in heptane) afforded the title compound (1.2 g, 91%) as a light yellow solid. MS ISP (m/e): 249.1 [(M+H)+].

1. temperatureAfter cooling to room temperature the mixture
2. customwas evaporated
3. customPurification by chromatography (silica gel, 3×70 g, 50 to 100% ethyl acetate in heptane)